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Luspatercept-aamt (By injection)

Luspatercept-aamt (lus-PAT-er-sept - aamt)

Treats anemia in patients with beta thalassemia who need regular blood transfusions.

Brand Name(s):

Reblozyl

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not use it if you had an allergic reaction to luspatercept-aamt, or if you are pregnant or breastfeeding.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
  • A nurse or other health provider will give you this medicine.
  • Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how luspatercept-aamt works. Tell your doctor if you are using birth control pills or hormone replacement medicines.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control during treatment with this medicine and for at least 3 months after the last dose.
  • Do not breastfeed while you are using this medicine and for at least 3 months after the last dose.
  • Tell your doctor if you have kidney disease, liver disease, high blood pressure, or a history of blood clots. Tell your doctor if you also have had surgery to remove your spleen (splenectomy) or if you smoke.
  • This medicine may cause the following problems:
    • Increased risk of blood clots (including deep vein thrombosis, ischemic strokes, portal vein thrombosis, pulmonary embolus)
    • High blood pressure
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision, dizziness, nervousness, headache, slow or fast heartbeat
  • Bone pain
  • Chest pain, trouble breathing, coughing up blood
  • Fever, chills, cough, sore throat, stuffy or runny nose, body aches
  • Numbness or weakness in your arm or leg, or on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Pain or swelling in your lower leg (calf)
  • Unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Cough
  • Diarrhea, nausea, stomach pain
  • Joint or muscle pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 5/1/2020

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