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Fedratinib (By mouth)

Fedratinib (fed-RA-ti-nib)

Treats myelofibrosis.

Brand Name(s):

Inrebic

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to fedratinib.

How to Use This Medicine:

Capsule

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • You may take this medicine with or without food. However, taking this medicine with a high fat meal may prevent nausea and vomiting.
  • You may also receive medicines to help prevent diarrhea, nausea, and vomiting.
  • Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how fedratinib works. Tell your doctor if you are using diltiazem, erythromycin, ketoconazole, metoprolol, midazolam, omeprazole, pantoprazole, or ruxolitinib.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if your are pregnant, or if you have kidney disease, liver disease, blood problems (including anemia, thrombocytopenia), or Vitamin B1 deficiency.
  • Do not breastfeed during treatment and for at least 1 month after the last dose.
  • This medicine may cause encephalopathy (brain disease), including Wernicke's encephalopathy, which may be serious and life-threatening.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, painful urination
  • Confusion, drowsiness, blurred vision, shaking, trembling, trouble remembering, problems with balance or walking
  • Fever, chills, cough, sore throat, body aches
  • Tiny red dots on the skin, especially on the lower legs
  • Unusual bleeding, bruising, and weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, vomiting, weight loss
  • Headache, dizziness
  • Muscle spasms

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 5/1/2020

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