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Dolutegravir/lamivudine (By mouth)

Dolutegravir (doe-loo-TEG-ra-vir), Lamivudine (la-MIV-ue-deen)

Treats HIV infection. This medicine does not cure HIV or AIDS, but it may slow the progress of the disease.

Brand Name(s):

Dovato

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to dolutegravir or lamivudine.

How to Use This Medicine:

Tablet

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is low so you do not run out.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with dofetilide.
  • Some medicines can affect how dolutegravir/lamivudine works. Tell your doctor if you are using any of the following:
    • Metformin, rifampin, sorbitol, St John's wort
    • Medicine to treat seizures (including carbamazepine, oxcarbazepine, phenobarbital, phenytoin)
  • Take this medicine at least 2 hours before or 6 hours after you take sucralfate, or an antacid, laxative, or other medicine that contains aluminum, calcium, magnesium, or iron.
  • Supplements that contain calcium or iron (including multivitamins) may be taken with this medicine if you take them with food.

Warnings While Using This Medicine:

  • Do not use this medicine during the first three months of your pregnancy. Use an effective form of birth control to keep from getting pregnant. Tell your doctor right away if you think you have become pregnant.
  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.
  • Tell your doctor if you have kidney disease or liver disease (including hepatitis B or C).
  • This medicine may cause the following problems:
    • Liver problems
    • Lactic acidosis (too much acid in the blood)
  • Your immune system may get stronger when you start using HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.
  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fast or troubled breathing, lightheadedness, fainting, severe weakness, tiredness, or confusion
  • Fever, chills, cough, sore throat, joint or muscle aches, severe tiredness, pain or swelling around your eye

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 3/19/2020

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