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Infliximab-dyyb (By injection)

Infliximab-dyyb (in-FLIX-i-mab - dyyb)

Treats ankylosing spondylitis, Crohn disease, plaque psoriasis, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to infliximab products or murine (mouse) proteins or if you have moderate to severe heart failure.

How to Use This Medicine:


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine must be given slowly, so the needle will have to remain in place for at least 2 hours.
  • You may also receive other medicines (including allergy medicine, fever medicine, steroids) before starting treatment to help prevent possible unwanted effects during the injection.
  • A nurse or other health provider will give you this medicine.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines may affect how infliximab-dyyb works. Tell your doctor if you are using any of the following:
    • Abatacept, anakinra, cyclosporine, theophylline, tocilizumab
    • Blood thinner (including warfarin)
    • Medicine that weakens immune system (including ciprofloxacin, methotrexate, metronidazole, aminosalicylate medicine, steroid)
  • Tell your doctor if you have had light treatment for psoriasis.
  • You should not receive a vaccine without your doctor's approval. A live virus vaccine could cause an infection. Children should be current on all vaccines before they start treatment with this medicine. If you received infliximab-dyyb while pregnant, tell the baby's doctor.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, heart disease, COPD, a bleeding disorder, blood or bone marrow problems, cancer, diabetes, or any type of infection. Tell your doctor if you have a history of seizures, multiple sclerosis, Guillain-Barré syndrome or a similar nervous system disease, or frequent or serious infections (including tuberculosis or hepatitis B).
  • This medicine may cause the following problems:
    • Increased risk for infections
    • Increased risk of certain cancers (including lymphoma, skin cancer, cervical cancer)
    • Liver problems
    • Infusion reaction (including heart attack, stroke, changes in blood pressure, or heart rhythm problems)
    • Lupus-like syndrome
  • You will need to have a skin test for tuberculosis (TB) before you start this medicine. Tell your doctor if you or anyone in your home has ever had a positive TB skin test or been exposed to TB.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, pain while urinating
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fever, chills, cough, runny or stuffy nose, sore throat, body aches
  • Headache, lightheadedness, trouble breathing
  • Joint or muscle pain, swelling, trouble swallowing
  • Seizures, numbness, tingling, problems with vision, speech, or walking
  • Unusual bleeding, bruising, tiredness, weakness
  • Warm, red, swollen, or painful skin, blisters, skin sores

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Redness, pain, or swelling where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

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