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Desmopressin (Under the tongue)

Desmopressin (des-moe-PRES-in)

Treats nocturnal polyuria (frequent urination and increased volume of urine at night).

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to desmopressin, or if you are thirsty most of the time and drink large amounts of fluids, have a condition called syndrome of inappropriate antidiuretic hormone, inflammation of the stomach or bowels, moderate to severe kidney disease, any type of infection, heart failure, or uncontrolled high blood pressure.

How to Use This Medicine:


  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Keep the tablet under your tongue until it has fully dissolved. Do not use this medicine with water.
  • Your doctor may instruct you to empty your bladder before bedtime.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with certain diuretics (water pill, including furosemide, torsemide) or systemic or inhaled glucocorticoids (including dexamethasone, fluticasone, methylprednisolone, prednisolone, prednisone).
  • Some medicines can affect how desmopressin works. Tell your doctor if you are using any of the following:
    • Medicine to treat depression (including SSRIs, TCAs)
    • Medicine to treat diabetes (including chlorpropamide)
    • Medicine to treat mental illness (including chlorpromazine)
    • Medicine to treat seizures (including carbamazepine, lamotrigine)
    • Narcotic pain reliever
    • NSAID pain or arthritis medicine (including aspirin, diclofenac, ibuprofen, naproxen)
    • Thiazide diuretic (water pill, including hydrochlorothiazide)
  • Limit the amount of fluids you drink from 1 hour before using this medicine and until 8 hours after. Also avoid drinks containing caffeine or alcohol before bedtime.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, increased pressure in the head, or a history of trouble passing urine.
  • This medicine may cause low levels of sodium in your blood and body swelling. Carefully follow your doctor's instructions about how much liquid to drink each day.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You may need to collect and measure your urine and the times that you urinate for 24 hours.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Confusion, weakness, muscle twitching
  • Rapid weight gain, swelling of your feet, legs, or ankles

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

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