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Voretigene Neparvovec-rzyl (By injection)

Voretigene Neparvovec-rzyl (vor-ET-i-jeen ne-PAR-voe-vek - rzyl)

Treats retinal dystrophy (inherited loss of vision).

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is generally considered safe for most people. Talk to your doctor if you have concerns.

How to Use This Medicine:


  • Your doctor will give you this medicine through a needle into your retina.
  • You may be given other medicines (including an oral steroid medicine) during treatment with this medicine.
  • Your doctor may want you to lie down as much as possible for 24 hours after treatment.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have eye infections.
  • This medicine may cause the following problems:
    • Endophthalmitis (inflammation of the inside of the eye)
    • Retinal problems, including a tear or hole in the eye
    • Increased pressure in the eye
    • Cataract
  • Avoid air travel, traveling to places with high elevations, or scuba diving for at least 1 week.
  • Be careful when handling your clothes or other materials that have been wet by your tears or nose secretions. This medicine may still be present for up to 7 days after treatment.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision or any change in vision, flashes of light, floating dark spots or material before your eyes
  • Pain, irritation, or swelling in the eye

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

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