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Ertugliflozin/metformin (By mouth)

Ertugliflozin (er-too-gli-FLOE-zin), Metformin Hydrochloride (met-FOR-min hye-droe-KLOR-ide)

Treats type 2 diabetes.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to ertugliflozin or metformin.

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • It is best to take this medicine with food or milk.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how ertugliflozin/metformin works. Tell your doctor about all other medicines that you are using, including the following:
    • Acetazolamide, cimetidine, dichlorphenamide, dolutegravir, isoniazid, nicotinic acid, phenytoin, ranolazine, vandetanib, zonisamide
    • Birth control pills (including estrogen)
    • Blood pressure medicine
    • Diuretic (water pill)
    • Medicine to treat mental illness
    • Steroid medicine
    • Thyroid medicine
  • Several other medicines may affect your blood sugar levels. Closely monitor your blood sugar levels when you start or stop another medicine while you are using ertugliflozin/metformin.
  • Limit the amount of alcohol you drink. Heavy alcohol use or binge drinking increases your risk for lactic acidosis.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.
  • Tell your doctor if have kidney disease, liver disease, heart failure, blood vessel disease, nerve problems, high cholesterol, adrenal or pituitary gland problem, vitamin B12 deficiency, or a history of pancreas problems, leg surgery or foot ulcers, or urinary tract or genital yeast infections. Tell your doctor if you are on a low-salt diet.
  • This medicine may cause the following problems:
    • Lactic acidosis (too much acid in the blood)
    • Low blood pressure
    • Ketoacidosis (high ketones and acid in the blood)
    • Kidney problems
    • Increased risk of genital yeast or urinary tract infections
    • Increased risk for lower leg or toe amputation (removal)
    • Low blood sugar, when used with other diabetes medicine
    • Fournier's gangrene (skin or tissue damage of the area between the anus and genitals)
    • High cholesterol level
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, bloody urine, difficult or painful urination, lower back or side pain, chills
  • Fast or troubled breathing, nausea, vomiting, stomach pain, severe weakness
  • Lightheadedness, dizziness, fainting
  • Pain, tenderness, redness, or swelling of the in the area between the anus and genitals, fever, unusual tiredness or weakness
  • Pain, tenderness, sores or ulcers, or infections on the leg or foot
  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion

If you notice these less serious side effects, talk with your doctor:

  • White or yellow vaginal or penile discharge, vaginal or penile itching or odor

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 2/4/2020

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