Sofosbuvir/velpatasvir/voxilaprevir (By mouth)
Sofosbuvir (soe-FOS-bue-vir), Velpatasvir (vel-PAT-as-vir), Voxilaprevir (vox-i-LA-pre-vir)
Treats chronic hepatitis C infection.
VoseviThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. Do not use it if you had an allergic reaction to sofosbuvir, velpatasvir, or voxilaprevir.
How to Use This Medicine:
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
- It is best to take this medicine with food or milk.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep this medicine in its original container.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Amiodarone can cause serious side effects if used together with sofosbuvir or if you have used it recently.
- Do not use this medicine together with rifampin.
- Some medicines can affect how sofosbuvir/velpatasvir/voxilaprevir works. Tell your doctor if you are using any of the following:
- Cyclosporine, dabigatran, digoxin, imatinib, irinotecan, lapatinib, methotrexate, mitoxantrone, rifabutin, rifapentine, St John's wort, sulfasalazine, topotecan
- Medicine to lower cholesterol (including atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin)
- Medicine to treat HIV infection (including atazanavir, efavirenz, lopinavir, tenofovir, tipranavir/ritonavir)
- Medicine to treat seizures (including carbamazepine, oxcarbazepine, phenobarbital, phenytoin)
- Take this medicine 4 hours before or after you take antacids containing aluminum or magnesium.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, other liver disease (including hepatitis B), or heart disease.
- This medicine may cause the following problems:
- Increased risk of reactivation of hepatitis B
- Worsening of liver problems
- Slow and uneven heartbeat when taken with amiodarone
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dark urine, pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Fainting, dizziness, lightheadedness
- Slow or uneven heartbeat
If you notice these less serious side effects, talk with your doctor:
- Tiredness or weakness, trouble sleeping
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 5/1/2020
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