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Ocrelizumab (By injection)

Ocrelizumab (ok-re-LIZ-ue-mab)

Treats multiple sclerosis.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to ocrelizumab, or if you have an active hepatitis B infection.

How to Use This Medicine:


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • Your doctor may give you other medicines (including an allergy medicine, fever medicine, steroid) before each infusion of this medicine to prevent unwanted effects. Your doctor may also want you to stay for at least 1 hour after your infusion to check for unwanted effects.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how ocrelizumab works. Tell your doctor if you are using any of the following:
    • Daclizumab, fingolimod, mitoxantrone, natalizumab, or teriflunomide
    • Steroid medicine
  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines. You may receive live or live-attenuated vaccines at least 4 weeks, or non-live vaccines at least 2 weeks, before starting this medicine.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control during treatment with this medicine and for 6 months after the last dose.
  • Tell your doctor if you are breastfeeding or if you have liver disease, cancer, or any type of infection.
  • This medicine may cause the following problems:
    • Infusion reactions, which can be life-threatening
    • Increase risk for infection, including herpes, lung or breathing infections, hepatitis B, or progressive multifocal leukoencephalopathy
    • Increase risk for cancer (including breast cancer)
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Cold sores or blisters on the lips, nose, eyes, or genitals
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat
  • Fever, chills, cough, runny or stuffy nose, sore throat, body aches
  • Lightheadedness, dizziness, fainting
  • Trouble breathing, headache
  • Unusual bleeding, bruising, or weakness
  • Warmth or redness in your face, neck, arms, or upper chest

If you notice these less serious side effects, talk with your doctor:

  • Back pain
  • Diarrhea
  • Feeling depressed or sad
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

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