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Dabrafenib (By mouth)

Dabrafenib (da-BRAF-e-nib)

Treats melanoma (skin cancer), non-small cell lung cancer (NSCLC), and anaplastic thyroid cancer (ATC).

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to dabrafenib or if you are pregnant.

How to Use This Medicine:


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Take this medicine at least 1 hour before or 2 hours after a meal. Allow about 12 hours between each dose.
  • Swallow the capsule whole. Do not open, crush, or break it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: If it is more than 6 hours until the time you normally take a dose, take it as soon as you remember. If it is less than 6 hours until your regular time, skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how dabrafenib works. Tell your doctor if you are also using clarithromycin, dexamethasone, gemfibrozil, ketoconazole, midazolam, nefazodone, warfarin, or birth control pills.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (including condoms or spermicide) along with your pills. Use an effective form of birth control during treatment with this medicine and for at least 2 weeks after the last dose.
  • Do not breastfeed during treatment with this medicine and for at least 2 weeks after the last dose.
  • Tell your doctor if you have kidney disease, liver disease, heart disease, diabetes, low blood pressure, or G6PD deficiency. Tell your doctor if you plan to have surgery, including dental surgery.
  • This medicine may cause the following problems:
    • Increased risk for other cancers (skin and non-skin cancer)
    • Increased risk of bleeding
    • Heart problems
    • Eye or vision problems
    • Fever (which may be serious)
    • Severe skin rash or infections
    • High blood sugar
  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate
  • Eye pain, vision changes, sensitivity to light
  • Fever, especially with stiff muscles, dizziness or lightheadedness
  • Increased hunger or thirst
  • Redness, swelling, peeling, or tenderness of the hands or feet
  • Trouble breathing, uneven heartbeat, rapid weight gain, swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness
  • Warts, skin sores, or reddish bumps that do not heal

If you notice these less serious side effects, talk with your doctor:

  • Back, joint, or muscle pain
  • Constipation, diarrhea, nausea, vomiting
  • Dry skin, rash
  • Hair loss
  • Headache
  • Thickened skin

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 3/19/2020

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

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