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Elvitegravir/cobicistat/emtricitabine/tenofovir (By mouth)

Cobicistat (koe-BIK-i-stat), Elvitegravir (el-vi-TEG-ra-vir), Emtricitabine (em-trye-SYE-ta-been), Tenofovir Disoproxil Fumarate (ten-OF-oh-vir dye-soe-PROX-il FUE-ma-rate)

Treats HIV infection. HIV causes AIDS. This medicine does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to elvitegravir, cobicistat, emtricitabine, or tenofovir.

How to Use This Medicine:


  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even for a short time, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.
  • It is best to take this medicine with food or milk.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the medicine in the original bottle. Keep the bottle tightly closed.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with alfuzosin, carbamazepine, cisapride, dihydroergotamine, ergotamine, lomitapide, lovastatin, lurasidone, methylergonovine, oral midazolam, phenobarbital, phenytoin, pimozide, rifampin, sildenafil, simvastatin, St John's wort, or triazolam.
  • There are many other drugs that can interact with this medicine. Make sure your doctor knows about all other medicines you are using, especially any of the following:
    • Acyclovir, atorvastatin, bosentan, buprenorphine/naloxone, cidofovir, clonazepam, colchicine, cyclosporine, dexamethasone, ethosuximide, fluticasone, ganciclovir, ledipasvir/sofosbuvir, oxcarbazepine, quetiapine, rifabutin, rifapentine, salmeterol, sirolimus, sofosbuvir/velpatasvir, tacrolimus, valacyclovir, valganciclovir
    • Birth control pills (including drospirenone/ethinyl estradiol, levonorgestrel, norgestimate/ethinyl estradiol)
    • Blood pressure medicine (including amlodipine, diltiazem, felodipine, metoprolol, nicardipine, nifedipine, timolol, verapamil)
    • Blood thinner (including apixaban, betrixaban, dabigatran, edoxaban, rivaroxaban, warfarin)
    • Medicine for depression or mental health problems (including amitriptyline, bupropion, desipramine, imipramine, nortriptyline, paroxetine, trazodone)
    • Medicine for heart rhythm problems (including amiodarone, bepridil, digoxin, disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine)
    • Medicine to treat an infection (including clarithromycin, itraconazole, gentamicin, ketoconazole, voriconazole)
    • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, fentanyl, ibuprofen, naproxen, tramadol)
    • Platelet aggregation inhibitor (including clopidogrel, ticagrelor)
    • Steroid medicine (including beclomethasone, budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone, mometasone, prednisolone, triamcinolone)
  • Take antacids or supplements containing aluminum, calcium, iron, magnesium, or zinc at least 2 hours before or after you take this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or planning to become pregnant, or if you have kidney disease, liver disease (including hepatitis B), or bone problems (including osteoporosis).
  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.
  • This medicine may cause the following problems:
    • Worsening of hepatitis B infection
    • Kidney problems
    • Lactic acidosis
    • Severe liver problems
    • Lower bone mineral density
    • Autoimmune problems (including Graves disease, polymyositis, Guillain-Barré syndrome, hepatitis)
  • Your immune system may get stronger when you start taking HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.
  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bone, joint, or muscle pain
  • Change in how much or how often you urinate, cloudy urine
  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
  • Fast breathing, trouble breathing, nausea and vomiting, lightheadedness, severe weakness, tiredness, confusion

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Headache
  • Unusual dreams

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 10/6/2020

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