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Ibuprofen/famotidine (By mouth)

Famotidine (fam-OH-ti-deen), Ibuprofen (eye-bue-PROE-fen)

Treats pain and arthritis. This medicine contains an NSAID and a medicine to protect your stomach from damage caused by the NSAID.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to ibuprofen, aspirin, famotidine, or similar medicines. Do not use right before or right after a heart surgery, called coronary artery bypass graft (CABG).

How to Use This Medicine:


  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Swallow the tablet whole. Do not break, crush, divide, or chew it.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use any other NSAID unless your doctor says it is okay. Some other NSAIDs are aspirin, diflunisal, naproxen, or salsalate.
  • Some medicines can affect how this medicine works. Tell your doctor if you are using any of the following:
    • Aspirin, cefditoren, cholestyramine, cyclosporine, dasatinib, delavirdine, digoxin, fosamprenavir, lithium, methotrexate, pemetrexed, tizanidine
    • Blood pressure medicine
    • Blood thinner (including warfarin)
    • Diuretic (water pill)
    • Medicine to treat depression
    • Steroid medicine
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant. Do not use this medicine during the later part of pregnancy.
  • Tell your doctor if you are breastfeeding or if you have kidney disease, liver disease, asthma, bleeding problems, heart or blood vessel problems, heart failure, a recent heart attack, high blood pressure, lupus, or a history of ulcers or other digestive problems. Tell your doctor if you smoke or drink alcohol.
  • This medicine may cause the following problems:
    • Increased risk of blood clots, heart attack, stroke, or heart failure
    • Bleeding problems, including stomach and bowel bleeding or ulcer
    • High blood pressure
    • Liver problems
    • Kidney problems
    • Serious skin reactions
    • Seizures
    • Changes in vision
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Bloody or black, tarry stools, severe stomach pain, vomiting blood or material that looks like coffee grounds
  • Chest pain that may spread, trouble breathing, coughing up blood, unusual sweating, fainting
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
  • Decrease in how much or how often you urinate, rapid weight gain, swelling in your hands, ankles, or feet
  • Fast, slow, or pounding heartbeat
  • Fever, neck pain, or stiff neck
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Seizures
  • Unusual bleeding, bruising or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea
  • Stomach upset

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 8/28/2020

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

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