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Lanreotide (Under the skin)

Lanreotide (lan-REE-oh-tide)

Treats acromegaly (a growth hormone disorder), carcinoid syndrome, and tumors in the stomach, bowels, or pancreas.

Brand Name(s):

Somatuline Depot

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to lanreotide, or if you are breastfeeding.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
  • A nurse or other health provider will give you this medicine.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how lanreotide works. Tell your doctor if you are using any of the following:
    • Bromocriptine, cyclosporine, quinidine, terfenadine
    • Blood pressure or heart medicine (including beta-blockers)
    • Insulin or oral diabetes medicine

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, diabetes, gallbladder disease, heart and blood vessel problems, or thyroid problems.
  • Do not breastfeed while you are using this medicine and for 6 months after the last dose.
  • This medicine may cause the following problems:
    • Gallstones, which may lead to swelling of the gallbladder, bile ducts, or pancreas
    • Changes in blood sugar level
    • High blood pressure
  • This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Talk with your doctor before using this medicine if you plan to have children. Some women who use this medicine have become infertile (unable to have children).
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Increased thirst, hunger, or urination
  • Severe stomach pain with nausea and vomiting, yellow skin or eyes, stomach fullness, fever
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, confusion
  • Slow heartbeat, trouble breathing
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Constipation, diarrhea, gas
  • Headache, dizziness
  • Joint or muscle pain
  • Pain, itching, or a lump under your skin where the shot is given
  • Weight loss

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 2/4/2020

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