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Benzoin compound/podophyllum (On the skin)

Benzoin Compound (BEN-zoyn KOM-pownd), Podophyllum (pode-oh-FIL-um)

Treats genital warts.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to benzoin compound or podophyllum, or if you have diabetes, trouble with blood circulation, or are using steroid medicines (such as dexamethasone, prednisone, or Medrol®). This medicine is not used to treat moles, birthmarks, irritated or bleeding warts, or unusual warts with hair growing from them. You should not use this medicine if you are pregnant.

How to Use This Medicine:


  • Your doctor will give you this medicine. This medicine will be left on your skin for a short period of time, usually about 1 to 4 hours.
  • Use this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.
  • If you have too many warts or if your warts cover a large skin area, your doctor may give you this medicine a second time.

If a dose is missed:

  • If you miss an appointment, call your doctor for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not put cosmetics or skin care products on the treated skin.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever, chills, cough, sore throat, and body aches.
  • Numbness, tingling, or burning pain on your skin or in your hands, arms, legs, or feet.
  • Stomach pain, constipation, nausea, or vomiting.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Skin rash, itching, or redness.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

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