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Ibuprofen lysine (By injection)

Ibuprofen Lysine (eye-bue-PROE-fen LYE-seen)

Treats a heart condition known as patent ductus arteriosus (PDA) in premature babies. This drug is an NSAID.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. This medicine should not be given if your child had an allergic reaction to ibuprofen lysine, or if your child has congenital heart disease, active bleeding, blood clotting problems, serious stomach or bowel problems (including necrotizing enterocolitis), or serious kidney problems.

How to Use This Medicine:


  • A nurse or other health professional will give your child this medicine.
  • This medicine must be given slowly to your child through the IV port, which is already in place, for over 15 minutes.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines may affect how ibuprofen lysine works. Tell your doctor if your child is also receiving amikacin or diuretics (water pill).

Warnings While Using This Medicine:

  • Tell your doctor if your child has any infection or bleeding problems.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • High fever, chills, sore throat, cough, body aches
  • Unusual bleeding, bruising, or weakness
  • Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

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