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Naloxone (By injection)

Naloxone (nal-OX-one)

Treats narcotic overdose in an emergency situation.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to naloxone.

How to Use This Medicine:


  • This medicine is given as a shot under your skin or into a muscle.
  • This medicine comes with patient instructions and a training device. You, your home health caregiver, and family members should read the instructions carefully. Ask your doctor if you have any questions.
  • Do not use the medicine if it is cloudy, discolored, or has large particles in it.
  • The autoinjector can be used only on time. Do not remove the red safety guard until you are ready to use it.
  • This medicine is available in 2 dosage strengths: 0.4 milligram (mg)/0.4 milliliter (mL) autoinjector and 2 mg/0.4mL autoinjector.
  • To use:
    • Inject the medicine into the outer thigh, through clothing, if needed. If you are giving this medicine to a child younger than 1 year of age, pinch the thigh while you give the medicine.
    • After you give the first dose to the patient, get emergency medical help right away.
    • Closely watch the patient after the injection for signs and symptoms of an opioid emergency.
    • Give a new injection every 2 to 3 minutes if symptoms return.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or heart disease.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Crying more than the usual (in babies)
  • Diarrhea, nausea, vomiting, stomach cramps
  • Fast, pounding, or uneven heartbeat, trouble breathing
  • Fever, runny nose, sneezing, sweating, yawning
  • Seizures, tremors, feeling restless, nervous, or irritable

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

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