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Indomethacin (By injection)

Indomethacin (in-doe-METH-a-sin)

Used in premature babies born with heart disease such as patent ductus arteriosus.

Brand Name(s):

Indomethacin Novaplus, PremierPro Rx Indomethacin

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Your child should not receive this medicine if he or she has had an allergic reaction to indomethacin, or if your child has an untreated infection, kidney problems, or certain intestinal problems or bleeding problems. Your child should not receive this medicine if he or she has congenital heart disease such as pulmonary atresia, severe tetralogy of Fallot, or severe coarctation of the aorta.

How to Use This Medicine:


  • This medicine is given to your child through a needle placed in one of the veins.
  • A nurse or other trained health professional will give this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your child's doctor knows all the medicines your child is receiving such as furosemide (Lasix®), digitalis (Digitek®, Lanoxin®) or medicines to treat an infection such as amikacin or gentamicin.

Warnings While Using This Medicine:

  • Make sure your doctor knows if your child has kidney disease, a bleeding disorder, or bleeding in the brain, stomach, or intestines.
  • Make sure your child's doctor knows if your child has any infection or liver disease.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Blood in your child's stools.
  • Bluish-colored skin.
  • Decrease in number of wet diapers each day.
  • Drowsiness or seizures.
  • Severe vomiting or bloated belly.
  • Trouble breathing.
  • Uneven or slow heart beat.
  • Unusual bleeding, or bruising.

If you notice these less serious side effects, talk with your doctor:

  • Fever.
  • Mild vomiting.
  • Mild skin rash.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

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