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Penicillin G benzathine/penicillin G procaine (By injection)

Penicillin G Benzathine (pen-i-SIL-in G BEN-za-theen), Penicillin G Procaine (pen-i-SIL-in G PROE-kane)

Treats infections. This medicine is an antibiotic.

Brand Name(s):

Bicillin C-R, Bicillin CR 900/300

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to penicillin or procaine.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles. Do not inject into or near an artery or nerve.
  • A nurse or other health provider will give you this medicine.
  • Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how penicillin G benzathine/penicillin G procaine works. Tell your doctor if you are using any of the following:
    • Acetaminophen, chloroquine, metoclopramide, primaquine, probenecid, quinine, sulfasalazine
    • Cancer medicine (including cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase)
    • Medicine to treat an infection (including dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamide, tetracycline)
    • Medicine to treat depression
    • Medicine to treat seizures (including phenobarbital, sodium valproate)
    • Nitrate or nitrite medicine (including nitric oxide, nitroglycerin, nitroprusside, nitrous oxide)
    • Medicines to make you numb (including articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine)

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heart problems, lung or breathing problems, a blood disorder, G6PD deficiency, or a history of asthma or allergies, including a previous allergic reaction to a cephalosporin antibiotic.
  • This medicine may cause methemoglobinemia (blood disorder).
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. It may occur 2 months or more after you stop using this medicine.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Diarrhea that may contain blood, stomach pain
  • Pale, gray, or blue lips, nails, or skin, dark urine, headache, lightheadedness, unusual tiredness or weakness, troubled breathing

If you notice these less serious side effects, talk with your doctor:

  • Pain, itching, burning, swelling, or a lump under your skin where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 5/1/2020

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