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Dicyclomine (By injection)

Dicyclomine (dye-SYE-kloe-meen)

Treats irritable bowel syndrome.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to dicyclomine, if you are breastfeeding, or if you have glaucoma, myasthenia gravis, a bowel blockage, an enlarged prostate, or reflux esophagitis.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how dicyclomine works. Tell your doctor if you are using amantadine, digoxin, metoclopramide, an MAO inhibitor (MAOI), a narcotic pain medicine (such as meperidine), medicine for heart rhythm problems (such as quinidine), an antihistamine, medicine to treat depression, a phenothiazine, or a steroid medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant, or if you have liver disease, kidney disease, GERD, ulcerative colitis, autonomic neuropathy, or any heart or blood vessel problems, including heart rhythm problems, heart failure, or high blood pressure.
  • This medicine may make you sweat less, which makes your body more sensitive to heat. This can cause heat stroke. Avoid activities, such as intense exercise, and weather that may cause you to overheat. Make sure you do not become dehydrated.
  • This medicine may make you drowsy or dizzy, or cause blurry vision. Do not drive or doing anything else that could be dangerous if you are not alert or cannot see well.
  • This medicine is not for long-term use.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Confusion, fever, weakness, hot, dry skin
  • Decrease in how much or how often you urinate
  • Diarrhea, constipation, nausea, vomiting, stomach pain
  • Fast, slow, or uneven heartbeat
  • Restlessness, agitation, trouble speaking or walking

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth
  • Pain or swelling where the shot was given
  • Sleepiness
  • Vision changes, dizziness, sensitivity of eyes to light

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 8/28/2020

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