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Mesna (By injection)

Mesna (MES-na)

Lowers the risk of inflammation and bleeding of the bladder in patients who receive ifosfamide (cancer medicine).

Brand Name(s):

Mesnex, PremierPro Rx Mesna

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to mesna. This medicine contains benzyl alcohol and should not be given to premature or low-birth weight babies.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems. Drink 1 to 2 liters of fluid each day.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • This medicine is used together with ifosfamide. Ifosfamide can harm your unborn baby while you are pregnant. It may also cause birth defects if the father is receiving it when his sexual partner becomes pregnant. Use an effective form of birth control during treatment with this medicine in combination with ifosfamide and for 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 3 months after the last dose.
  • Do not breastfeed during treatment with this medicine and for 1 week after the last dose.
  • Tell your doctor if you have a history of an allergic reaction to thiol compounds (including amifostine).
  • This medicine may cause serious skin reactions.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Chest pain, trouble breathing, fast or uneven heartbeat
  • Fever, chills, cough, sore throat, body aches
  • Lightheadedness, dizziness, fainting
  • Red or pink urine
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, constipation, stomach pain
  • Loss of appetite, nausea, vomiting
  • Loss or thinning of hair
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • Unusual drowsiness or tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 5/1/2020

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