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Fluconazole (By injection)

Fluconazole (floo-KON-a-zole)

Prevents and treats fungal infections.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive this medicine if you had an allergic reaction to fluconazole, or if you are pregnant.

How to Use This Medicine:


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not receive this medicine if you are using astemizole, cisapride, erythromycin, pimozide, quinidine, or terfenadine.
  • Some foods and medicine can affect how fluconazole works. Tell your doctor if you are using cimetidine, midazolam, prednisone, rifabutin, rifampin, theophylline, tofacitinib, triazolam, vitamin A supplements, or voriconazole. Also tell your doctor if you are using any of the following:
    • A blood thinner (such as warfarin)
    • A diuretic or "water pill" (such as hydrochlorothiazide), or blood pressure medicine (such as amlodipine, felodipine, isradipine, losartan, nifedipine)
    • Birth control pills
    • Cancer medicine (cyclophosphamide, vinblastine, vincristine)
    • Diabetes medicine that you take by mouth (glipizide, glyburide, tolbutamide)
    • Medicine to lower cholesterol (atorvastatin, fluvastatin, simvastatin)
    • Medicine to treat depression (amitriptyline, nortriptyline)
    • Medicine to treat HIV/AIDS (saquinavir, zidovudine)
    • Medicine to treat malaria (halofantrine)
    • Medicine to treat seizures (carbamazepine, phenytoin)
    • Medicine that weakens the immune system (cyclosporine, sirolimus, tacrolimus)
    • Narcotic pain medicine (alfentanil, fentanyl, methadone)
    • Pain or arthritis medicine (aspirin, celecoxib, diclofenac, ibuprofen, naproxen)

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, heart rhythm problems (such as QT prolongation), cancer, or HIV/AIDS.
  • This medicine may cause the following problems:
    • Liver problems
    • Serious skin reactions
    • Changes in heart rhythm, such as a condition called QT prolongation
  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild nausea, vomiting, stomach pain, or diarrhea
  • Pain, itching, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

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