Hypophosphatemia is a low level of phosphorus in the blood.
Low blood phosphate; Phosphate - low; Hyperparathyroidism - low phosphate
The following may cause hypophosphatemia:
- Certain medicines, including insulin, acetazolamide, foscarnet, imatinib, intravenous iron, niacin, pentamidine, sorafenib, and tenofovir
- Fanconi syndrome
- Fat malabsorption in the gastrointestinal tract
- Hyperparathyroidism (overactive parathyroid gland)
- Too little vitamin D
Symptoms may include:
- Bone pain
- Muscle weakness
Exams and Tests
Your health care provider will examine you.
The following tests may be done:
- Kidney function tests
- Vitamin D blood test
Exam and testing may show:
Treatment depends on the cause. Phosphate can be given by mouth or through a vein (IV).
How well you do depends on what has caused the condition.
When to Contact a Medical Professional
Call your provider if you have muscle weakness or confusion.
Chonchol M, Smogorzewski MJ, Stubbs, JR, Yu ASL. Disorders of calcium, magnesium, and phosphate balance. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 18.
Klemm KM, Klein MJ. Biochemical markers of bone metabolism. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 15.
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.