Barbiturate anticonvulsant medications includes:
Taking mephobarbital, primidone, or their metabolite, phenobarbital, may deplete calcium, vitamin A, vitamin B9, and vitamin D with long-term use.
Calcium, along with vitamin D, keeps your bones strong and healthy.
Low levels of calcium may cause:
Low levels of folic acid in the body may be linked to:
Symptoms may include:
Vitamin D, along with calcium, keeps your bones strong and healthy.
Low levels of vitamin D may cause:
Low levels of vitamin A may cause:
The information presented here covers some of the nutrients that may be affected when you take certain medicines. If you have any of these signs and symptoms, it does not always mean you have low levels of these nutrients.
Factors that affect the level of nutrients are:
Please talk to your health care provider. They can best address your health care needs and see if you are at risk for low levels of any nutrients.
Asiedu DK. Vitamin deficiency (Hypovitaminosis). In: Ferri FF, ed. Ferri's Clinical Advisor 2017. Philadelphia, PA: Elsevier; 2017:1359-1360.
Dominiczak MH, Broom JI. Vitamins and minerals. In: Baynes JW, Dominiczak MH, eds. Medical Biochemistry. 4th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 11.
Gold Standard Drug Database. Drug Monograph: Phenobarbital. 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-171. Accessed July7, 2016.
Gold Standard Drug Database. Drug Monograph: Primidone. 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-508. Accessed July 12, 2016.
Gold Standard Drug Database. Drug Monograph: Mephobarbital. 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-1433. Accessed July 12, 2016.
Greenbaum LA. Vitamin K deficiency. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 53.
Shenkin A, Roberts NB. Vitamins and trace elements. In: Burtis CA, Ashwood ER, Bruns DE, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 5th ed. St. Louis, MO: Elsevier Saunders; 2012:chap 31.
Smogorzewski MJ, Stubbs JR, Yu ASL. Disorders of calcium, magnesium, and phosphate balance. In: Skorecki K, Chertow GM, Marsden PA, Yu ASL, Taal MW, eds. Brenner and Rector's The Kidney. 10th ed. Philadelphia, PA: Elsevier; 2016:chap 19.
Review Date: 9/19/2016
Reviewed By: Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network. Also reviewed by the A.D.A.M. Editorial team.
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