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Semaglutide (By injection)

Semaglutide (sem-a-GLOO-tide)

Treats type 2 diabetes. Lowers the risk of heart attack or stroke in patients with type 2 diabetes and heart or blood vessel disease.

Brand Name(s):

Ozempic 0.25 MG or 0.5 MG Doses, Ozempic 1 MG Doses

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to semaglutide, or if you have multiple endocrine neoplasia syndrome type 2 (MEN 2) or if you or anyone in your family has had medullary thyroid cancer.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. It is given into your stomach, thigh, or upper arm.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • If you use insulin in addition to this medicine, do not mix them into the same syringe. You may give the shots in the same area (including your stomach), but do not give the shots right next to each other.
  • Check the liquid in the pen. It should be clear and colorless. Do not use it if it is cloudy, discolored, or has particles in it.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use a new needle and syringe each time you inject your medicine.
  • Never share medicine pens with others under any circumstances. Sharing needles or pens can result in transmission of infection.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: If you miss a dose of this medicine, use it as soon as possible within 5 days after the missed dose. If you miss a dose for more than 5 days, skip the missed dose and go back to your regular dosing schedule.
  • Store your new, unused medicine pen in its original carton in the refrigerator. Do not freeze. You may store the opened medicine pen in the refrigerator or at room temperature for 56 days. Throw away the pen after you use it for 56 days, even if it still has medicine in it.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines may affect how semaglutide works. Tell your doctor if you are using other diabetes medicine (including glimepiride, glipizide, glyburide, or insulin) or any oral medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, pancreas problems, digestion problems, or a history of diabetic retinopathy.
  • This medicine may cause the following problems:
    • Increased risk of thyroid tumor
    • Pancreatitis (swelling of the pancreas)
    • Low blood sugar (when used with other diabetes medicine)
    • Kidney problems
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision or any other change in vision
  • Decrease in how much or how often you urinate, lower back or side pain, blood in your urine
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
  • Sudden and severe stomach pain, nausea, vomiting, fever

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Redness, itching, bump, swelling, or any changes in your skin where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

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