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Ibuprofen (By injection)

Ibuprofen (eye-bue-PROE-fen)

Treats fever and pain. This medicine is an NSAID.

Brand Name(s):

Caldolor, Neoprofen

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction (including asthma) to ibuprofen, aspirin, or another NSAID. Do not use if you have had heart surgery, including coronary artery bypass graft.

How to Use This Medicine:


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how ibuprofen works. Tell your doctor if you are using any of the following:
    • Aspirin, cyclosporine, digoxin, lithium, methotrexate, pemetrexed
    • Blood thinner (including warfarin)
    • Blood pressure medicine
    • Diuretic (water pill)
    • Medicine to treat depression
    • Steroid (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of pregnancy.
  • Tell your doctor if you have kidney disease, liver disease, asthma, bleeding problems, heart disease, recent heart attack, heart failure, high blood pressure, or a history of ulcers or other digestive problems. Tell your doctor if you drink alcohol or smoke.
  • This medicine may cause the following problems:
    • Higher risk of heart attack, stroke, or heart failure
    • Higher risk of bleeding problems, including stomach ulcer or bleeding
    • Liver damage
    • High blood pressure
    • Kidney damage
    • Higher levels of potassium in the blood
    • Serious skin reactions
    • Changes in vision
    • Aseptic meningitis

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Blurred vision, changes in color vision
  • Change in how much or how often you urinate
  • Chest pain that may spread, trouble breathing, unusual sweating, fainting
  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
  • Fever, stiff neck, nausea or vomiting
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Severe stomach pain, vomiting blood, bloody or black, tarry stools
  • Unusual bleeding, bruising, or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 6/18/2019

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

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