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Allantoin/pramoxine (On the skin)

Allantoin (a-LAN-toin), Pramoxine (pram-OX-een)

Treats cold sores and severely dry or chapped lips.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to allantoin or pramoxine.

How to Use This Medicine:


  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Follow the instructions on the medicine label if you are using this medicine without a prescription.
  • Use this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.
  • Apply this medicine 3 to 4 times each day.
  • To treat dry or chapped lips, apply enough medicine to cover your lips completely.
  • To treat a cold sore, apply this medicine as soon as you notice the first signs of tingling or blistering. Treat a cold sore as early as possible for the best results.
  • You may apply lipstick or other cosmetics after applying this medicine to your lips.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Do not use this medicine on a child under 2 years of age unless your doctor tells you to.
  • This medicine does not contain an antibiotic. It is made only for use on the lips to treat cold sores or chapped lips. Do not use this medicine to treat minor cuts or scrapes.
  • This medicine will not kill the virus that causes cold sores (also known as herpes simplex). It will relieve the tingling, burning, and pain of a cold sore.
  • Until your cold sore heals completely, you can pass the herpes virus to someone else through skin-to-skin contact. Do not allow your lips to come into contact with the skin of another person while you have a cold sore.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • No improvement in your condition after using this medicine for 7 days.
  • Worsened symptoms.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

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